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KMID : 0880420170180050799
Korean Journal of Radiology
2017 Volume.18 No. 5 p.799 ~ p.808
Percutaneous Dual-Switching Monopolar Radiofrequency Ablation Using a Separable Clustered Electrode: A Preliminary Study
Choi Tae-Won

Lee Jeong-Min
Lee Dong-Ho
Lee Jeong-Hoon
Yu Su-Jong
Kim Yoon-Jun
Yoon Jung-Hwan
Han Joon-Koo
Abstract
Objective: To prospectively evaluate the safety and therapeutic effectiveness of dual-switching monopolar (DSM) radiofrequency ablation (RFA) for the treatment of hepatocellular carcinoma (HCC), and to retrospectively compare the results with those of single-switching monopolar (SSM) RFA in a historical control group.

Materials and Methods: This study was approved by the Institutional Review Board, with informed consent obtained from all patients. Fifty-two HCC patients who underwent DSM-RFA using a separable clustered electrode and dual-generators were prospectively enrolled. Technical parameters, complications, technical success, technical effectiveness, and local tumor progression (LTP) rates were evaluated by means of post-procedural and follow-up imaging. Thereafter, the outcome of DSM-RFA was compared with those of 249 retrospectively included HCC patients treated with SSM-RFA.

Results: There were two major complications (3.8%, 2/52) including pleural and pericardial effusion in the DSM-RFA group. The DSM-RFA yielded a 100% technical success rate, a 98.1% technical effectiveness rate, and a 4.3% 2-year LTP rate. In a retrospective comparison between the two groups, DSM-RFA created significantly larger ablation volume (4.20 ¡¾ 2.07 cm3/min vs. 3.03 ¡¾ 1.99 cm3/min, p < 0.01), and delivered higher energy (1.43 ¡¾ 0.37 kcal/min vs. 1.25 ¡¾ 0.50 kcal/min, p < 0.01) per given time, than SSM-RFA. There was no significant difference in major procedure-related complications (3.8% vs. 4.4%) and technical effectiveness rate (98.1% vs. 96.4%) between the two groups (p = 1.00). In addition, the 2-year LTP rate of DSM-RFA and SSM-RFA were 4.3% and 10.1%, respectively (p = 0.15).

Conclusion: DSM-RFA using a separable clustered electrode is safe and provides high local tumor control and good preliminary clinical outcome for small HCCs, which are at least comparable to those of SSM-RFA.
KEYWORD
Liver, Hepatocellular carcinoma, Local ablation therapy, Radiofrequency ablation, Therapeutic efficacy
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