KMID : 0880420180190020247
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Korean Journal of Radiology 2018 Volume.19 No. 2 p.247 ~ p.255
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Self-Gated Late Gadolinium Enhancement at 7T to Image Rats with Reperfused Acute Myocardial Infarction
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Wang Lei
Chen Yushu Zhang Bing Chen Wei Wang Chunhua Song Li Xu Ziqian Zheng Jie Gao Fabao
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Abstract
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Objective: A failed electrocardiography (ECG)-trigger often leads to a long acquisition time (TA) and deterioration in image quality. The purpose of this study was to evaluate and optimize the technique of self-gated (SG) cardiovascular magnetic resonance (CMR) for cardiac late gadolinium enhancement (LGE) imaging of rats with myocardial infarction/reperfusion.
Materials and Methods: Cardiovascular magnetic resonance images of 10 rats were obtained using SG-LGE or ECG with respiration double-gating (ECG-RESP-gating) method at 7T to compare differences in image interference and TA between the two methods. A variety of flip angles (FA: 10¡Æ?80¡Æ) and the number of repetitions (NR: 40, 80, 150, and 300) were investigated to determine optimal scan parameters of SG-LGE technique based on image quality score and contrast-to-noise ratio (CNR).
Results: Self-gated late gadolinium enhancement allowed successful scan in 10 (100%) rats. However, only 4 (40%) rats were successfully scanned with the ECG-RESP-gating method. TAs with SG-LGE varied depending on NR used (TA: 41, 82, 154, and 307 seconds, corresponding to NR of 40, 80, 150, and 300, respectively). For the ECG-RESP-gating method, the average TA was 220 seconds. For SG-LGE images, CNR (42.5 ¡¾ 5.5, 43.5 ¡¾ 7.5, 54 ¡¾ 9, 59.5 ¡¾ 8.5, 56 ¡¾ 13, 54 ¡¾ 8, and 41 ¡¾ 9) and image quality score (1.85 ¡¾ 0.75, 2.20 ¡¾ 0.83, 2.85 ¡¾ 0.37, 3.85 ¡¾ 0.52, 2.8 ¡¾ 0.51, 2.45 ¡¾ 0.76, and 1.95 ¡¾ 0.60) were achieved with different FAs (10¡Æ, 15¡Æ, 20¡Æ, 25¡Æ, 30¡Æ, 35¡Æ, and 40¡Æ, respectively). Optimal FAs of 20¡Æ?30¡Æ and NR of 80 were recommended.
Conclusion: Self-gated technique can improve image quality of LGE without irregular ECG or respiration gating. Therefore, SG-LGE can be used an alternative method of ECG-RESP-gating.
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KEYWORD
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Self-gated, Myocardial infarction, Flip angle, MRI, Late gadolinium enhancement, Animal studies, 7T
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