KMID : 0880420180190061021
|
|
Korean Journal of Radiology 2018 Volume.19 No. 6 p.1021 ~ p.1030
|
|
Development and Validation of Generalized Linear Regression Models to Predict Vessel Enhancement on Coronary CT Angiography
|
|
Masuda Takanori
Nakaura Takeshi Funama Yoshinori Sato Tomoyasu Higaki Toru Kiguchi Masao Matsumoto Yoriaki Yamashita Yukari Imada Naoyuki Awai Kazuo
|
|
Abstract
|
|
|
Objective: We evaluated the effect of various patient characteristics and time-density curve (TDC)-factors on the test bolus-affected vessel enhancement on coronary computed tomography angiography (CCTA). We also assessed the value of generalized linear regression models (GLMs) for predicting enhancement on CCTA.
Materials and Methods: We performed univariate and multivariate regression analysis to evaluate the effect of patient characteristics and to compare contrast enhancement per gram of iodine on test bolus (¥ÄHUTEST) and CCTA (¥ÄHUCCTA). We developed GLMs to predict ¥ÄHUCCTA. GLMs including independent variables were validated with 6-fold cross-validation using the correlation coefficient and Bland?Altman analysis.
Results: In multivariate analysis, only total body weight (TBW) and ¥ÄHUTEST maintained their independent predictive value (p < 0.001). In validation analysis, the highest correlation coefficient between ¥ÄHUCCTA and the prediction values was seen in the GLM (r = 0.75), followed by TDC (r = 0.69) and TBW (r = 0.62). The lowest Bland?Altman limit of agreement was observed with GLM-3 (mean difference, ?0.0 ¡¾ 5.1 Hounsfield units/grams of iodine [HU/gI]; 95% confidence interval [CI], ?10.1, 10.1), followed by ¥ÄHUCCTA (?0.0 ¡¾ 5.9 HU/gI; 95% CI, ?11.9, 11.9) and TBW (1.1 ¡¾ 6.2 HU/gI; 95% CI, ?11.2, 13.4).
Conclusion: We demonstrated that the patient's TBW and ¥ÄHUTEST significantly affected contrast enhancement on CCTA images and that the combined use of clinical information and test bolus results is useful for predicting aortic enhancement.
|
|
KEYWORD
|
|
MDCT, Computed tomography, Heart, Aorta contrast medium, Aortic enhancement, Cardiac output
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|