|
KMID : 0880420200210020218
|
|
Korean Journal of Radiology
2020 Volume.21 No. 2 p.218 ~ p.227
|
|
|
B-Value Optimization in the Estimation of Intravoxel Incoherent Motion Parameters in Patients with Cervical Cancer
|
|
Perucho Jose Angelo Udal
Chang Hing Chiu Charles
Vardhanabhuti Varut
Wang Mandi
Becker Anton Sebastian
Wurnig Moritz Christoph
Lee Elaine Yuen Phin
|
|
|
Abstract
|
|
|
Objective: This study aimed to find the optimal number of b-values for intravoxel incoherent motion (IVIM) imaging analysis, using simulated and in vivo data from cervical cancer patients.
Materials and Methods: Simulated data were generated using literature pooled means, which served as reference values for simulations. In vivo data from 100 treatment-naive cervical cancer patients with IVIM imaging (13 b-values, scan time, 436 seconds) were retrospectively reviewed. A stepwise b-value fitting algorithm calculated optimal thresholds. Feed forward selection determined the optimal subsampled b-value distribution for biexponential IVIM fitting, and simplified IVIM modeling using monoexponential fitting was attempted. IVIM parameters computed using all b-values served as reference values for in vivo data.
Results: In simulations, parameters were accurately estimated with six b-values, or three b-values for simplified IVIM, respectively. In vivo data showed that the optimal threshold was 40 s/mm2 for patients with squamous cell carcinoma and a subsampled acquisition of six b-values (scan time, 198 seconds) estimated parameters were not significantly different from reference parameters (individual parameter error rates of less than 5%). In patients with adenocarcinoma, the optimal threshold was 100 s/mm2, but an optimal subsample could not be identified. Irrespective of the histological subtype, only three b-values were needed for simplified IVIM, but these parameters did not retain their discriminative ability.
Conclusion: Subsampling of six b-values halved the IVIM scan time without significant losses in accuracy and discriminative ability. Simplified IVIM is possible with only three b-values, at the risk of losing diagnostic information.
|
|
|
KEYWORD
|
|
|
Cervical cancer, Magnetic resonance imaging, Diffusion-weighted imaging, Intravoxel incoherent motion, b-values
|
|
|
FullTexts / Linksout information
|
|
  
|
|
|
Listed journal information
|
|
    
|
|