KMID : 0880420210220020189
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Korean Journal of Radiology 2021 Volume.22 No. 2 p.189 ~ p.197
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Serial Observations of Muscle and Fat Mass as Prognostic Factors for Deceased Donor Liver Transplantation
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Lee Ji-Sun
Jeong Woo-Kyoung Kim Jae-Hun Kim Jong-Man Kim Tae-Yeob Choi Gyu-Seong Kwon Choon-Hyuck David Joh Jae-Won Eom Sang-Yong
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Abstract
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Objective: Muscle depletion in patients undergoing liver transplantation affects the recipients' prognosis and therefore cannot be overlooked. We aimed to evaluate whether changes in muscle and fat mass during the preoperative period are associated with prognosis after deceased donor liver transplantation (DDLT).
Materials and Methods: This study included 72 patients who underwent DDLT and serial computed tomography (CT) scans. Skeletal muscle index (SMI) and fat mass index (FMI) were calculated using the muscle and fat area in CT performed 1 year prior to surgery (1 yr Pre-LT), just before surgery (Pre-LT), and after transplantation (Post-LT). Simple aspects of serial changes in muscle and fat mass were analyzed during three measurement time points. The rate of preoperative changes in body composition parameters were calculated (preoperative ¥ÄSMI [%] = [SMI at Pre-LT ? SMI at 1 yr Pre-LT] / SMI at Pre-LT ¡¿ 100; preoperative ¥ÄFMI [%] = [FMI at Pre-LT ? FMI at 1 yr Pre-LT] / FMI at Pre-LT ¡¿ 100) and assessed for correlation with patient survival.
Results: SMI significantly decreased during the preoperative period (mean preoperative ¥ÄSMI, ?13.04%, p < 0.001). In the multivariable analysis, preoperative ¥ÄSMI (p = 0.016) and model for end-stage liver disease score (p = 0.011) were independent prognostic factors for overall survival. The mean survival time for patients with a threshold decrease in the preoperative ¥ÄSMI (¡Â ?30%) was significantly shorter than for other patients (p = 0.007). Preoperative ¥ÄFMI was not a prognostic factor but FMI increased during the postoperative period (p = 0.009) in all patients.
Conclusion: A large reduction in preoperative SMI was significantly associated with reduced survival after DDLT. Therefore, changes in muscle mass during the preoperative period can be considered as a prognostic factor for survival after DDLT.
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KEYWORD
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Liver transplantation, Sarcopenia, Computed tomography, Preoperative period, Survival
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