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KMID : 0880420210220101650
Korean Journal of Radiology
2021 Volume.22 No. 10 p.1650 ~ p.1657
Metastatic Mature Teratoma and Growing Teratoma Syndrome in Patients with Testicular Non-Seminomatous Germ Cell Tumors
Green Daniel B.

La Rosa Francisco G.
Craig Paul G.
Khani Francesca
Lam Elaine T.
Abstract
Metastatic mature teratoma is a common radiologic and histopathologic finding after chemotherapy for metastatic non-seminomatous germ cell tumors. The leading theory for these residual tumors is the selective chemotherapy resistance of teratomas versus the high chemotherapy sensitivity of the embryonal components. Growing teratoma syndrome is a relatively rare phenomenon defined as an enlarging residual mass histologically proven to be a mature teratoma in the setting of normal serum tumor markers. Metastatic mature teratomas should be resected because of their malignant potential and occasional progression to growing teratoma syndrome with the invasion of the surrounding structures. CT is the preferred imaging modality for post-chemotherapy surveillance and should cover all sites of potential metastatic disease. This article reviews the clinical, pathologic, and multimodality imaging features of metastatic mature teratomas in patients with primary testicular non-seminomatous germ cell tumors.
KEYWORD
Metastatic mature teratoma, Growing teratoma syndrome, Non-seminomatous germ cell tumor, Testicular cancer, Surveillance imaging
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