Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0880420210220101680
Korean Journal of Radiology
2021 Volume.22 No. 10 p.1680 ~ p.1689
Diagnostic Yield of Diffusion-Weighted Brain Magnetic Resonance Imaging in Patients with Transient Global Amnesia: A Systematic Review and Meta-Analysis
Lim Su-Jin

Kim Min-Jae
Suh Chong-Hyun
Kim Sang-Yeong
Shim Woo-Hyun
Kim Sang-Joon
Abstract
Objective: To investigate the diagnostic yield of diffusion-weighted imaging (DWI) in patients with transient global amnesia (TGA) and identify significant parameters affecting diagnostic yield.

Materials and Methods: A systematic literature search of the MEDLINE and EMBASE databases was conducted to identify studies that assessed the diagnostic yield of DWI in patients with TGA. The pooled diagnostic yield of DWI in patients with TGA was calculated using the DerSimonian-Laird random-effects model. Subgroup analyses were also performed of slice thickness, magnetic field strength, and interval between symptom onset and DWI.

Results: Twenty-two original articles (1732 patients) were included. The pooled incidence of right, left, and bilateral hippocampal lesions was 37% (95% confidence interval [CI], 30?44%), 42% (95% CI, 39?46%), and 25% (95% CI, 20?30%) of all lesions, respectively. The pooled diagnostic yield of DWI in patients with TGA was 39% (95% CI, 27?52%). The Higgins I2 statistic showed significant heterogeneity (I2 = 95%). DWI with a slice thickness ¡Â 3 mm showed a higher diagnostic yield than DWI with a slice thickness > 3 mm (pooled diagnostic yield: 63% [95% CI, 53?72%] vs. 26% [95% CI, 16?40%], p < 0.01). DWI performed at an interval between 24 and 96 hours after symptom onset showed a higher diagnostic yield (68% [95% CI, 57?78%], p < 0.01) than DWI performed within 24 hours (16% [95% CI, 7?34%]) or later than 96 hours (15% [95% CI, 8?26%]). There was no difference in the diagnostic yield between DWI performed using 3T vs. 1.5T (pooled diagnostic yield, 31% [95% CI, 25?38%] vs. 24% [95% CI, 14?37%], p = 0.31).

Conclusion: The pooled diagnostic yield of DWI in TGA patients was 39%. DWI obtained with a slice thickness ¡Â 3 mm or an interval between symptom onset and DWI of > 24 to 96 hours could increase the diagnostic yield.
KEYWORD
Transient global amnesia, Magnetic resonance imaging, Diffusion-weighted imaging, Systematic review and meta-analysis, Diagnostic yield
FullTexts / Linksout information
  
Listed journal information
SCI(E) MEDLINE ÇмúÁøÈïÀç´Ü(KCI) KoreaMed ´ëÇÑÀÇÇÐȸ ȸ¿ø