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KMID : 0880420230240060512
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Korean Journal of Radiology
2023 Volume.24 No. 6 p.512 ~ p.521
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Left Atrial Strain Derived From Cardiac Magnetic Resonance Imaging Can Predict Outcomes of Patients With Acute Myocarditis
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Lee Ji-Min
Choo Ki-Seok
Jeong Yeon-Joo
Lee Gee-Won
Muzahidul Islam
Maria Roselle Abraham
Lee Ji-Won
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Abstract
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Objective : There is increasing recognition that left atrial (LA) strain can be a prognostic marker of various cardiac diseases. However, its prognostic value in acute myocarditis remains unclear. Therefore, this study aimed to evaluate whether cardiovascular magnetic resonance (CMR)-derived parameters of LA strain can predict outcomes in patients with acute myocarditis.
Materials and Methods : We retrospectively analyzed the data of 47 consecutive patients (44.2 ± 18.3 years; 29 males) with acute myocarditis who underwent CMR in 13.5 ± 9.7 days (range, 0?31 days) of symptom onset. Various parameters, including feature-tracked CMR-derived LA strain, were measured using CMR. The composite endpoints included cardiac death, heart transplantation, implantable cardioverter-defibrillator or pacemaker implantation, rehospitalization following a cardiac event, atrial fibrillation, or embolic stroke. The Cox regression analysis was performed to identify associations between the variables derived from CMR and the composite endpoints.
Results : After a median follow-up of 37 months, 20 of the 47 (42.6%) patients experienced the composite events. In the multivariable Cox regression analysis, LA reservoir and conduit strains were independent predictors of the composite endpoints, with an adjusted hazard ratio per 1% increase of 0.90 (95% confidence interval [CI], 0.84?0.96; P = 0.002) and 0.91 (95% CI, 0.84?0.98; P = 0.013), respectively.
Conclusion : LA reservoir and conduit strains derived from CMR are independent predictors of adverse clinical outcomes in patients with acute myocarditis.
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KEYWORD
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Myocarditis, Magnetic resonance imaging, Major adverse cardiovascular events, Left atrium
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