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KMID : 0893319860010010037
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Journal of Environmental Toxicology
1986 Volume.1 No. 1 p.37 ~ p.46
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The Effect of Ginseng Petroleum Ether Fraction on Immunosuppressed Mice by Lead acetate (II) II. Cellular Immune Response and Histological Studies
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Kim Hwi-Bae
Ahn Young-Keun
Kim Zoo-Young
Moon Jae-Kyu
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Abstract
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Experiments were performed to investigate the effect of Panax ginseng petroleum ether fraction on delayed type hypersensitivity, rosette formation, phagocytic activity and histophathological influence in lead acetate treated mice. Lead acetate was administered in the drinking water and ginseng pet. ether fraction was injected i.p.. Mice were sensitized and challenged with sheep red blood cells. Erythrocyte(I) rosette formation and DTH reaction were significantly depressed in lead acetate treated mice, and those were restored administration of ginseng fraction. Ginseng pet. ether fraction administration did not have any effect on decreased phagocytic activity. Follicular and parafollicular areal destruction of spleen, and destruction of thymus were finded in lead acetate exposed-mice. Small dose of ginseng pet. ether fraction (5 mg/kg, 10 mg/kg), administraction inhibited those histopathological changes, but large dose (20 mg/kg) didn’t.
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