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KMID : 0893319890040030001
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Journal of Environmental Toxicology
1989 Volume.4 No. 3 p.1 ~ p.6
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Studies on the Bis (amino-alkyl-oxo) Oxalate Derivatives As a Antidote of Lead poisoning
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Choi Seon-Ah
You Mi-Rhe
Rho Young-Soo
Chung Sung-Hyun
Choung Se-Young
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Abstract
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The effects of his (-amino-ethyl-oxo) oxalate and bis (-amino-methyl-oxo) oxalate on the toxicity of lead acetate in rast were examined. Rats were given intraperitoneally at the dose of lead acetate 45 mg/kg. The exposure of lead acetate showed the 70% decrease of ALAD (-amino levulinic acid dehydratase) activity in red blood cell. In vivo 122 mg/kg administration of bis (-amino-ethyl-oxo) oxalate and bis (-amino-methyl-oxo) oxalate showed the 50% increase of ALAD activity, whereas 149 mg/kg administeration of Ca-EDTA had no effect. In vitro, the same results were obtained. Both compounds had hemolytic activity at concentrations higher than that required for showing the 50% ALAD activity increase in vivo.
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