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KMID : 0893319890040030015
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Journal of Environmental Toxicology
1989 Volume.4 No. 3 p.15 ~ p.28
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Effect of Ethanol on the Toxicity of 2.4-Dichlorophenoxyacetic Acid
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Ahn Young-Keun
SunWoo Yeon
Chung Jong-Gab
Kim Joung-Hoon
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Abstract
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The effects of ethanol on the toxicity of 2, 4-Dichlorophenoxyacetic acid in ICR mice were examined. The results were summerized as follows; 1. The LD50/ of 2.4-dichlorphenoxyacetic acid sodium injected intraperitoneally in mice was approximately 367 mg/kg. When the animals were administered with ethanol, 2 ml/kg or 4 ml/kg the LD50/ of 2.4-D sodium were decreased to 338 mg/kg or 32 mg/kg, respectively. 2. In the acute experimental group, spontaneous motor activity in the ANIMEX system exhibited dose-dependent decrease in mice administered with 2.4-D sodium and ethanol. 3. However, in subacute experimental group, spontaneous motor activity in the ANIMEX system exhibited dose-dependent increase in mice treated with ethanol.
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