|
KMID : 0893319940090010001
|
|
Journal of Environmental Toxicology
1994 Volume.9 No. 1 p.1 ~ p.8
|
|
|
Effects of lead on ATPase activity in the sciatic nerve of Sprague-Dawley rat
|
|
Chung Myung-Kiu
|
|
|
Abstract
|
|
|
|
Nerve conduction impairment in lead neuropathy has been empirically linked to altered nerve myo-inositol metabolism. In most cases of neuropathy, abnormal myo-inositol metabolism is associated with abnormal ATPase provides a potential mechanism to relate defects of the myo-inositol metabolism in the peripheral nerve treated with lead. Therefore, the effect of lead on the rat sciatic nerve ATPase and other ATPase of sciatic nerve was studied. ATPase activity was measured enzymatically in sciatic nerve homogenates from 2-wk lead treated neuropathy rats and age-mached controls administered myo-inositol. ATPase components were assessed by ouabain inhibition or the omission of sodium and potassium ions. Lead reduced 50% reduction in the ATPase activity in homogenates of sciatic nerve. The 50% reduction in the ATPase activity was selectively prevented by myo-inositol treatment. This study suggests that the toxic mechanism of the lead on peripheral nerve may be through reduction in ATPase activity which has been linked to axonal transport slowing in the rat model of lead neuropathy, via direct changes by the perturbation of the intracelluar sodium or potasium level.
|
|
|
KEYWORD
|
|
|
lead neuropathy, ATPase activity, myo-inositol
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|