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KMID : 0893320000150010031
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Journal of Environmental Toxicology
2000 Volume.15 No. 1 p.31 ~ p.37
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Initial Risk Assessment of Acetanilide with Respect to Human Health
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Lee Su-Rae
Choi Seon-Ju
Lee Mi-Kyung
Nam Woo-Kyong
Chung Sun-Hwa
Seog Guem-Su
Park Kwang-Sik
Kim Kyun
Kim Yong-Hwa
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Abstract
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Acetanilide may be released into the environment through air and wastewater from its production and use sites and exposed to human. Acetanilide is known to produce an analgesic effect and may pose adverse effects on human health by overly exposure. According to the EUSES system, acetanilide showed a high MOS (Margin of safety) value exceeding 610 on a regional exposure, which is safe enough for public health. Whereas the lowest MOS value in dermal exposure was estimated as 310 on a local basis (workplace), the risk could be partly counteracted by taking preventive measures such as using mask and globes and good ventilation in the work places. Acetanilide may pose a potential risk for workers by dust inhalation. For the sake of health protection in the work places, additional data should be accumulated with respect to repeated dose toxicity, reproduction toxicity and developmental toxicity, etc. It is, therefore, recommended that acetanilide should be a candidate for further work to supplement the lacking data until it is proved to be safe in the occupational health aspects.
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