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KMID : 0893320020170020161
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Journal of Environmental Toxicology
2002 Volume.17 No. 2 p.161 ~ p.174
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Effects of an Extract from A. gmelini Weber on Hepatotoxicity Induced by CCl4 in Rats - I. Effects of an Extract from A. gmelini on Hepatotoxicity Induced by Different Levels of CCl4
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Kwon Jin-Wook
Lee Kyu-Seung
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Abstract
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To investigate effects of A. gmelini on the 14-day CClinduced hepatotoxicity, extracts were prepared in 3 ml saline at the dose of 5,000 mg/kg b.w. to administer orally once daily. Each concentration (5：5, 2：5 : 7.5, 1：9, CCl: olive oil v/v) of CClwas orally administered with 2.5 ml/kg b.w., During the experiment, halves of the rats were sacrificed every 7 day and hemanalysis was done. On the 7th day, hemanalysis showed following recovery values; AST 52.6∼61.4％, ALT 55.9∼86.1％, ALP 46.0∼70.9%, BUN 75.7∼100.0< ％, TBIL 55.2∼96.1％, TCHO 38.0∼63.7％, and TG 55.2∼96.0％. On the 14th day, recovery values of each treatment were GOT 37.7∼43.1％, GPT 19.8∼45.9％, ALP 58.1∼95.9％, BUN 57.6∼100.0< ％, TBIL 78.6∼100.0< ％, TCHO 56.9∼100.0< ％, and TG 10.0∼5l.2%. By histological examination of liver, hydropic degeneration, fatty change, lipid accumulation and necrosis were also recovered by administration of A. gmelini extract.
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KEYWORD
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A. gmelini extract, induced hepatotoxicity, lipid peroxidation
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