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KMID : 0893320020170020175
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Journal of Environmental Toxicology
2002 Volume.17 No. 2 p.175 ~ p.185
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Effects of an Extract from A. gmelini Weber on Hepatotoxicity Induced by in Rats - II. Some Dosage Effects of an Extract from A. gmelini on Hepatotoxicity Induced by in Rats
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Kwon Jin-Wook
Lee Kyu-Seung
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Abstract
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To investigate effects of A. gmelini on the 14-day CClinduced hepatotoxicity, extracts were prepared in 3 ml saline at the dose of 50, 500, 5,000 mg/kg b.w. to administer orally everyday and same concentration (1 : 9, CCl: olive oil v/v) of CCladministered intraperitoneally with 2.5 ml/kg b.w. On the 7th day, hemanalysis showed following recovery values; AST 9.9∼64.6%, ALT 36.9∼71.9%, ALP 75.3∼93.7％, BUN 53.8∼59.7%, TBIL 60.4∼100.0< ％, TCHO 77.7∼100.0< ％, and TG 60.4∼100.0< ％. Even if, 14-day CClinduced hepatotoxicity recovery was found to depend on doses of extract, and recovery values of each treatment were AST 13.8∼56.4％, ALT 15.7∼68.0％, ALP 53.4∼84.4％, BUN 76.9∼100.0< ％, TBIL 60.4 ∼ 100.0< %, TCHO 82.6∼99.3< ％, and TG 56.7∼99.7%. By histological examination of liver, hydropic degeneration, fatty change, lipid accumulation and necrosis were also recovered.
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KEYWORD
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A. gmelini extract, induced hepatotoxicity, lipid peroxidation
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