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KMID : 0893320050200020161
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Journal of Environmental Toxicology
2005 Volume.20 No. 2 p.161 ~ p.165
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Protective Effects of Angelica koreana on Experimentally Induced Liver Injury
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Yoon Soo-Hong
Ha Hyun
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Abstract
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The present study was carried out to find the possible protective effects of Angelica koreana water extract on biochemical parameters in benzo(a)pyrene (B(a)P)-induced liver injury in rats. B(a)P treatment (0.1 mg/kg, 1.p.) caused a liver damages, which led to biochemical alterations in serum and liver enzyme activities and serum lipid levels. The activities of liver marker enzymes, especially, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were markedly changed in B(a)P treatment. Oral administration of Angelica koreana (50 mg/kg) recovered these biochemical Parameters to near normal levels. Therefore, the present results have revealed that Angelica koreana water extract might have the antihepatotoxic effect and consequently ameliorate liver damage associated with B(a)P in rats.
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KEYWORD
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Angelica koreana, benzo(a)pyrene, antihepatotoxic effect
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