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KMID : 0893320050200030237
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Journal of Environmental Toxicology
2005 Volume.20 No. 3 p.237 ~ p.242
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Effect of Organic Sulfur-Containing Compounds on Hepatotoxicity in Rats Induced by N, N-Dimethylnitrosamine
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Shin Hea-Soon
Kang Joo-Yeon
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Abstract
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This study il focused on the hepatopreventive effect in cirrhotic rats induced by N, N -dimethylnitrosamine treatment when organir Lulfur -containing compoundE were orally injected. Biochemical parameters (aspatate transaminase (AST), alanine transaminase (ALT) alkaline phosphatase (ALP), 1-protein and t-bilirubin) were measured in serum injured liver tissue. The increased AST and ALT values were significantly reduced by organic sulfur-containing compounds at the oral dotes of 50 mg/kg. The result of morphological changes have illustrated the accumulation of liver damages, Each as inflammatory cell accumulation and cirrhosis, caused by N, N-dimethylnitrosamine. Also, it was found that liver damages were prevented by the treatment of organic sulfur- containing compounds.
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KEYWORD
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N, N-dimethylnitrosamine, organic sulfur-containing compounds
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