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KMID : 0893320050200040351
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Journal of Environmental Toxicology
2005 Volume.20 No. 4 p.351 ~ p.358
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Slow-Stirring Methods for Determining the n-Octanol/Water Partition Coefficient(Pow) of Highly Hydrophobic Chemicals
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Chang Hee-Ra
Lee Bong-Jae
Kim Kyun
Kim Yong-Hwa
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Abstract
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The n -octanol/water partition coefficient (Pow) is one of the most important parameters employed for estimating a chemiral’s environmental fate and toxicity. The shake-flask method, one direct experimental method, i.1 prone to experimental artifacts for highly hydrophobic compounds. Thus, a valid method for direct determination of the Pow of highly hydrophobic compounds is needed. The slow -stirring method has been demonstrated to provide reliable log Pow data to log Pow greater than 5. This study was performed to evaluate the accuracy of slow- stirring experiment for determination of log Pow, particularly for highly hydrophobic compounds. 1, 2, 3, 4-tetrachlorobenzene, hexachlorobezene, 2, 2’, 3, 3’, 5, 5’, 6, 6’-octachlorobiphenyl, decachlorobiphenyl, and p, p’-DDT (4.50.02, 5.410.06, 7.260.04, 7.870.10, and 6.030.06, respectively. The octanol/water partition coefficient by the slow-stirring method were very similar to the literature values. These results indicate that the slow- stirring method allows for reliable determination of log Pow of highly hydrophobic chemicals.
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KEYWORD
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Slow-stirring method, Hydrophobic chemicals, Octanol/water partition coefficient
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