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KMID : 0893320060210010087
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Journal of Environmental Toxicology
2006 Volume.21 No. 1 p.87 ~ p.92
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Effect of 9-Amino-1, 2, 3, 4-tetrahydroacridine on -Induced Liver Injury in Rats
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Shin Hea-Soon
Cho Eun-Jung
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Abstract
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This study was done to investigate the protective effect of novel 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives on the hepatoprotective effect intoxicated rats induced by carbon tetrachloride (). A series of currently derivatives of 9-amino-1, 2, 3, 4-tetrahydroacridine have been prepared through the alkly substitution or the ring expansion for the treatment of the Alzheimer’s disease. The activities of aminotransferase (aspartate and alanine) and contents of alkaline phosphatase, triglyceride and glutathione S-transferase in 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives pretreated rats were significantly decreased compared to the only carbon tetrachloride treated rats but the contents of cholesterol were increased compared to the only treated rats. The result indicated that 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives showed hepatoprotective effect in treated rats.
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KEYWORD
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hepatoprotective effect, 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives
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