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KMID : 0893320080230010023
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Journal of Environmental Toxicology
2008 Volume.23 No. 1 p.23 ~ p.32
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Effect of Genotoxicity or Carcinogenecity Chemicals on the ROS Production
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Go Seo-Youn
Sheen Yhun Yhong
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Abstract
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In the present study, ROS detection of L5178Y cells that were treated with twenty test compounds in order to find out hydrogen peroxide () induction for genotoxicity and carcinogenic toxicity. Twenty test compounds were consist of four classes, such as genotoxic carcinogens, genotoxic noncarcinogens, nongenotoxic carcinogens, and nongenotoxic noncarcinogens. Genotoxic carcinogens are 1,2-dibromoethane, glycidol, melphalan, diethylstilbestrol and urethane. Genotoxic noncarcinogens are 8-hydroxyquinoline, emodin, acetonitrile and diallylphthalate, L-ascorbic acid. Nongenotoxic carcinogens are methyl carbamate, O-nitrotoluene, 1,4-dioxane, tetrachloroethylene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. And nongenotoxic noncarcinogens are D-mannitol, 1,2-dichlorobenzene, caprolactam, bisphenol A and chlorpheniramine maleate.
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KEYWORD
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genotoxicity, carcinogenicity, oxidative stress, hydrogen peroxide
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