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KMID : 0893320080230010041
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Journal of Environmental Toxicology
2008 Volume.23 No. 1 p.41 ~ p.45
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Evaluation of Oxy-radical Scavenging Capacity of Fucoidan
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Kim Bong-Hee
Kang Keon-Wook
Kwak Sang-Hoon
Lee Chul-Ho
Lee Hyun-Sun
Kim Sang-Kyum
Yun Se-Young
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Abstract
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Algal fucoidan is a marine polysaccharide containing sulfur with a wide variety of biological activities including anti-inflammatory and anti-thrombotic effects. Although antioxidants can inhibit inflammatory signals through inhibiting activator protein-1 and/or nuclear factor-kappaB activation, it is obscure whether fucoidan directly scavenges oxy-radicals or indirectly regulates oxidant production and/or antioxidant defense system. The antioxidant activities of fucoidan against peroxyl radicals, peroxynitrites and hydroxyl radicals were determined by the total oxy-radical scavenging capacity (TOSC) assay. The specific TOSC values of fucoidan against peroxyl radicals, peroxynitrites or hydroxyl radicals were , or , respectively. These specific TOSC values against peroxyl radicals, peroxynitrites or hydroxyl radicals are 23, 12, or 13% of the specific TOSC values of glutathione, a positive control, respectively. These results suggest that fucoidan has direct oxy-radical scavenging capacity, which may be related with anti-inflammatory effect of fucoidan.
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KEYWORD
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fucoidan, oxy-radicals, TOSC, oxidative stress
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