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KMID : 0893320080230010047
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Journal of Environmental Toxicology
2008 Volume.23 No. 1 p.47 ~ p.51
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Research of Detection Method for Cytotoxic Effects of Environmental Pollutants Using Atomic Force Microscopy (AFM) in HeLa Cells
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Lee Si-Won
Lee Soo-Il
Choi Jin-Hee
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Abstract
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The toxicity of environmental pollutants was measured between a image of the surface topography in HeLa cells using atomic force microscopy for the possibility of toxic effect measurement and environmental monitoring. A image of the surface topography by AFM were estimated as toxic endpoints. The surface topography by AFM was observed a change of the cell surface in the environmental pollutants, but the standard of the measurement requires for the dose-effect degree. The overall results indicate that the possibility of measurement using AFM were confirmed a dose-effect degree related toxic effects, but it requres correlation between more various biomarker and AFM’s measurements if the possibility of the toxic effect measurement was established.
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KEYWORD
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atomic force microscopy (AFM), environmental pollutants, HeLa cells, toxicity
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