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KMID : 0893320080230010063
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Journal of Environmental Toxicology
2008 Volume.23 No. 1 p.63 ~ p.65
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Tissue Distribution of Nanoparticles in Mice after Oral Administration, and Skin Treatment
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Park Eun-Jung
Park Kwang-Sik
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Abstract
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The tissue distribution of , nanopaprticles was investigated in mice after oral administration, and skin treatment. Male mice were treated with the dose of 5 g/kg of for three consecutive days and sacrificed at 24 hours after the last administration. As results, the orally administered nanoparticels were shown to be distributed in the testis, lung, and brain at 24 hours after the last treatment. Kidney does not seem to be the main target of nanoparticle distribution. It means that nanoparticles (17 nm) are easily absorbed through entero-gastric system and may cause toxicity in brain, lung, and reproductive organs. The distribution of skin treatment showed the same pattern like oral administration.
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KEYWORD
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nanoparticles, tissue distribution, lung, brain, testis
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