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KMID : 0893320090240020127
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Journal of Environmental Toxicology
2009 Volume.24 No. 2 p.127 ~ p.136
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A Study of Mammalian Erythrocyte Micronucleus Induction with Aluminum Oxide, Calcium Oxide, Sodium Tetraborate
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Rim Kyung-Taek
Kim Soo-Jin
Kim Jong-Kyu
Kang Min-Gu
Kim Hyeon-Young
Yang Jeong-Sun
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Abstract
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We have investigated the genotoxicity of 3 chemicals, aluminum oxide, calcium oxide, sodium tetraborate using mammalian erythrocyte with micronucleus induction. It was performed using 9 week male ICR mice. At 24 hours after treatment with 3 chemicals with oral route, mice were sacrificed and bone marrow cells were prepared for smear slides. As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocytes (PCE), all treatment groups did not show statistically significant increase than negative control group. And there was no clinical sign related with injection of the 3 chemicals. It was concluded that the 3 chemicals did not induce micronucleus in the bone marrow cells of ICR mice, and these results indicate that the 3 chemicals have no mutagenic potential under the condition in each studies.
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KEYWORD
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mammalian, erythrocyte, micronucleus induction, aluminum oxide, calcium oxide, sodium tetraborate
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