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KMID : 0893420050060030247
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Journal of Veterinary Science
2005 Volume.6 No. 3 p.247 ~ p.250
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Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen
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Chang BS
Bohach GA/Lee SU/Davis WC/Fox LK/Ferens WA/Seo KS/Koo HC/Kwon NH/Park YH
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Abstract
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Our recent study has provided that the in vitro SEC-induced proliferation of bovine T cells is preceded by a period of a non-proliferative immunoregulation of T cells that may be associated with cytokine production regulated by type 1 or type 2 T cells. Inversion of CD4+:CD8+T cell ratio and induction of CD8+T cells with immunoregulatory activity could increase the probability of intracellular survival of Staphylococcus aureus (S. aureus ). The increase of activated CD8 +(ACT2+ BoCD8+ )T cells in cows with mastitis caused by S. aureus may be associated with immune-regulatory function in the bovine mammary gland. The difference and similarity between bovine activated CD8+T cells (CD8+ CD26+)and well-established human CD4+ CD25+ T regulatory (Tr)cells may help to reveal their unique immune regulatory system in the host infected with S. aureus.
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