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KMID : 0893420050060040353
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Journal of Veterinary Science
2005 Volume.6 No. 4 p.353 ~ p.355
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The anti-thrombotic activity of surfactins
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Lim JH
Park BK/Kim MS/Hwang MH/Rhee MH/Park SC/Yun HI
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Abstract
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Platelet aggregation was inhibited and the density of platelet-rich plasma (PRP) clots was decreased by the preincubation of PRP with surfactins, an acidic lipopeptide of Bacillus subtilis complex BC1212 isolated from soybean paste, in dose-dependent manner. Our findings suggest that surfactins are able to prevent a platelet aggregation leading to an inhibition of additional fibrin clot formation, and to enhance fibrinolysis with facilitated diffusion of fibrinolytic agents.
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