|
KMID : 0893420070080030249
|
|
Journal of Veterinary Science
2007 Volume.8 No. 3 p.249 ~ p.254
|
|
|
Metoclopramide protection of diazinon-induced toxicosis in chickens
|
|
Al-Zubaidy M.H.I
Mohammad F.K.
|
|
|
Abstract
|
|
|
|
The efficacy of metoclopramide for preventing organophosphate insecticide-induced (diazinon) toxicosis was evaluated in 7~14 days old chicks. Injection of metoclopramide at 25 mg/kg, s.c. 15 min before diazinon increased the oral 24 h median lethal dose of the insecticide in the chicks by 80%. Metoclopramide alone inhibited the in vitro and in vivo plasma and whole brain cholinesterase activities of the chicks. Metoclopramide pretreatment at 100 mg/kg, s.c. reduced the extent of cholinesterase inhibition that was caused by diazinon (10 mg/kg, p.o.) in the plasma and whole brain by 24% and 7%, respectively. Diazinon at 10 mg/kg, p.o. produced signs of cholinergic toxicosis in the chicks, and these signs included salivation, lacrimation, gasping and convulsions within 2 h, and the 2-h and 24-h lethalities were 88 and 100%, respectively. Metoclopramide at the dose rates of 12.5, 25, 50, 100 and 200 mg/kg, s.c. given 15 min before diazinon (10 mg/kg, p.o.) variably decreased the occurrence of toxic manifestations in the chicks. The highest dose of metoclopramide (200 mg/kg, s.c.) reduced the 2-h and 24-h lethality of diazinon to 75% each and it reduced the overall toxicity score of diazinon by 32%. The data suggest that metoclopramide pretreatment only partially protected chicks against the acute toxicity of diazinon
|
|
|
KEYWORD
|
|
|
cholinesterase, diazinon, metoclopramide, organophosphate, poisoning
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
   
|
|