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KMID : 0893420070080030299
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Journal of Veterinary Science
2007 Volume.8 No. 3 p.299 ~ p.301
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Identification of single-nucleotide polymorphisms of the prion protein gene in sika deer (Cervus nippon laiouanus)
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Jeong Hyun-Jeong
Lee Joong-Bok
Park Seung-Yong
Song Chang-Seon
Kim Bo-Sook
Rho Jung-Rae
Yoo Mi-Hyun
Kim Yong-Sun
Jeong Byung-Hoon
Choi In-Soo
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Abstract
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Polymorphisms of the prion protein gene (PRNP) have been detected in several cervid species. In order to confirm the genetic variations, this study examined the DNA sequences of the PRNP obtained from 33 captive sika deer (Cervus nippon laiouanus) in Korea. A total of three single-nucleotide polymorphisms (SNPs) at codons 100, 136 and 226 in the PRNP of the sika deer were identified. The polymorphic site located at codon 100 has not been reported. The SNPs detected at codons 100 and 226 induced amino acid substitutions. The SNP at codon 136 was a silent mutation that does not induce any amino acid change. The genotype and allele frequencies were determined for each of the SNPs.
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KEYWORD
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PRNP, sika deer, single-nucleotide polymorphism
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