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KMID : 0893420070080040353
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Journal of Veterinary Science
2007 Volume.8 No. 4 p.353 ~ p.356
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Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs
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Chang Zhi-Qiang
Oh Byung-Chol
Kim Jong-Choon
Jeong Kyu-Shik
Lee Myung-Heon
Yun Hyo-In
Hwang Mi-Hyun
Park Seung-Chun
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Abstract
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The pharmacokinetics and dosage regimen of norfloxacin- glycine acetate (NFLXGA) was investigated in pigs after a single intravenous (i.v.) or oral (p.o.) administration at a dosage of 7.2 mg/kg body weight. After both i.v. and p.o. administration, plasma drug concentrations were best fitted to an open two-compartment model with a rapid distribution phase. After i.v. administration of NFLXGA, the distribution (t1/2α) and elimination half-life (t1/2β) were 0.36 ± 0.07 h and 7.42 ± 3.55 h, respectively. The volume of distribution of NFLXGA at steady state (Vdss) was 4.66 ± 1.39 l/kg. After p.o. administration of NFLXGA, the maximal absorption concentration (Cmax) was 0.43 ± 0.06 μg/ ml at 1.36 ± 0.39 h (Tmax). The mean absorption (t1/2ka) and elimination half-life (t1/2β) of NFLXGA were 0.78 ± 0.27 h and 7.13 ± 1.41 h, respectively. The mean systemic bioavailability (F) after p.o. administration was 31.10 ± 15.16%. We suggest that the optimal dosage calculated from the pharmacokinetic parameters is 5.01 mg/kg per day i.v. or 16.12 mg/kg per day p.o.
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KEYWORD
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norfloxacin, pharmacokinetics, pig
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