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KMID : 0893420070080040369
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Journal of Veterinary Science
2007 Volume.8 No. 4 p.369 ~ p.376
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Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings
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Kang Byeong-Teck
Lee Jong-Hwan
Jung Dong-In
Park Chul
Gu Su-Hyun
Jeon Hyo-Won
Jang Dong-Pyo
Lim Chae-Young
Quan Fu-Shi
Kim Young-Bo
Cho Zang-Hee
Woo Eung-Je
Park Hee-Myung
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Abstract
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The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery occlusion in four healthy beagle dogs using silicone plugs. They showed neurological signs of forebrain dysfunction such as reduced responsiveness, head turning, circling, postural reaction deficits, perceptual deficits, and hemianopsia. These signs gradually regressed within 4 weeks without therapy. On magnetic resonance imaging, T2 hyperintensity and T1 hypointensity were found in the cerebral cortex and basal ganglia. These lesions were well-defined and sharply demarcated from adjacent brain parenchyma with a homogenous appearance. No abnormalities of the cerebrospinal fluid were observed. At necropsy, atrophic and necrotic lesions were observed in the cerebral cortex. The cerebral cortex, basal ganglia, and thalamus were partially unstained with triphenyl- tetrazolium chloride. Histopathologically, typical features of infarction were identified in cortical and thalamic lesions. This study demonstrates that our canine model resembles the conditions of real stroke patients.
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KEYWORD
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dog, histopathology, ischemic stroke, MCAO, MRI
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