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KMID : 0893420080090030241
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Journal of Veterinary Science
2008 Volume.9 No. 3 p.241 ~ p.245
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Disposition kinetics and urinary excretion of ciprofloxacin in goats following single intravenous administration
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Raina R.
Prawez S.
Dimitrova D.J.
Pankaj N.K.
Verma P.K.
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Abstract
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We evaluated the pharmacokinetics of ciprofloxacin in serum (n = 6) and urine (n = 4) in goats following a single intravenous administration of 4 mg/kg body weight. The serum concentration-time curves of ciprofloxacin were best fitted by a two-compartment open model. The drug was detected in goat serum up to 12 h. The elimination rate constant (β) and elimination half-life (t1/2β) were 0.446 ± 0.04 h-1 and 1.630 ± 0.17 h, respectively. The apparent volume of distribution at steady state (Vdss) was 2.012 ± 0.37 l/kg and the total body clearance (ClB) was 16.27 ± 1.87 ml/min/kg. Urinary recovery of ciprofloxacin was 29.70% ± 10.34% of the administered dose within 36 h post administration. In vitro serum protein binding was 41% ± 13.10%. Thus, a single daily intravenous dose of 4 mg/kg is sufficient to maintain effective levels in serum and for 36 h in urine, allowing treatment of systemic, Gram-negative bacterial infections and urinary tract infections by most pathogens.
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KEYWORD
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ciprofloxacin, disposition kinetics, goat, urinary excretion
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