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KMID : 0893420090100020165
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Journal of Veterinary Science
2009 Volume.10 No. 2 p.165 ~ p.167
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A novel β-glucan produced by Paenibacillus polymyxa JB115 induces nitric oxide production in RAW264.7 macrophages
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Chang Zhi-Qiang
Park Seung-Chun
Lee Sam-Pin
Hwang Mi-Hyun
Jung Hee-Kyoung
Hong Joo-Heon
Lee Joong-Su
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Abstract
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The effect of extracellular β-(1→3), (1→6)-glucan, produced by Paenibacillus polymyxa JB115, on nitric oxide (NO) production in RAW264.7 macrophages was investigated. β-glucan induced the production of NO by RAW264.7 macrophages in a concentration- and time-dependent manner. Moreover, β-glucan stimulation increased the mRNA expression of iNOS, COX-2 and IL-6 in RAW264.7 macrophages in a concentration-dependent manner.
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KEYWORD
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β-glucan, macrophages, nitric oxide, Paenibacillus polymyxa
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