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KMID : 0893420090100030177
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Journal of Veterinary Science
2009 Volume.10 No. 3 p.177 ~ p.180
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Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
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Lee Ju-Yeon
Lee Keun-Hwa
Joo Hong-Gu
Shin Tae-Kyun
Moon Chang-Jong
Ahn Mee-Jung
Jung Chan-Woo
Kim Ji-Hoon
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Abstract
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The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne’s disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infection was histochemically confirmed using Ziehl- Neelsen staining and molecularly diagnosed through rpoB DNA sequencing. Galectin-3 was detected in the majority of inflammatory cells, possibly macrophages, in the granulomatous lesions within affected tissues, including the ileum. These findings suggest that galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis, probably through cell adhesion and anti-apoptosis mechanisms.
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KEYWORD
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bovine paratuberculosis, galectin-3, granulation, intestine
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