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KMID : 0893420090100030239
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Journal of Veterinary Science
2009 Volume.10 No. 3 p.239 ~ p.247
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The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial
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Korakot Nganvongpanit
Peraphan Pothacharoen
Niyada Suwankong
Siriwan Ong-Chai
Kongtawelert Prachya
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Abstract
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Twenty-five dogs were included in a randomized, doubleblind trial to assess the efficacy of doxycycline (DOX) orally administered twice a day at 4 mg/kg/day (n = 12) for the treatment of osteoarthritis of the hip. Chondroitin sulfate (CS; 525 mg/day) was used as a positive control (n = 13). Dogs were re-examined monthly for 6 months after initiation of treatment. The assessment protocol included clinical score, radiographic findings and serum osteoarthritis biomarkers. Dogs treated with DOX showed statistically significant improvements (p ＜ 0.05) in lameness, joint mobility, pain on palpation, weight-bearing and overall score at 2, 6, 4, 4 and 4 months, respectively, after treatment. Biomarker levels of CS-WF6 epitope and hyaluronan were significantly increased and decreased (p ＜ 0.05) at 2 and 3 months after treatment compared to pretreatment. These results showed that DOX had a positive therapeutic effect in dogs with osteoarthritis.
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KEYWORD
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biomarkers, canine, chondroitin sulfate, doxycycline, osteoarthritis
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