KMID : 0893420090100040349
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Journal of Veterinary Science 2009 Volume.10 No. 4 p.349 ~ p.351
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A Serine12Stop mutation in PB1-F2 of the 2009 pandemic (H1N1) influenza A: a possible reason for its enhanced transmission and pathogenicity to humans
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Muthannan A. Ramakrishnan
Marie R. Gramer Sagar M. Goyal Srinand Sreevatsan
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Abstract
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As the scientific community scrambles to define the ancestry and lineages of the eight segments of new pandemic H1N1 strain, we looked for unique genetic events in this virus¡¯s genome to explain the newly found enhanced virulence and transmissibility among humans. Genome annotations of this virus identified a stop mutation replacing serine at codon 12 (S12Stop) of the PB1-F2 protein, a virulence factor in influenza A viruses. Here, we discuss the significance of this finding and how it may contribute to host specialization, explaining the virtual absence of the H1N1 influenza A virus strain in pig populations. This finding is expected to lead to a better understanding of the transmission and pathogenesis of the 2009 pandemic strain.
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KEYWORD
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pandemic influenza A, PB1-F2 protein, S12Stop, virulence marker
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