KMID : 0893420100110010035
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Journal of Veterinary Science 2010 Volume.11 No. 1 p.35 ~ p.41
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Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice
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Lee Soon-Hee
Heo Yong Kim Young-Chul
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Abstract
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Historically, German chamomile (GC) oil has been used for treatment of skin disorders. BALB/c mice were sensitized twice a week with 100 ¥ìL of 1% 2,4-dinitrochlorobenzene (DNCB) and challenged twice the following week with 100 ¥ìL of 0.2% DNCB for atopic dermatitis induction. Thereafter, 3% GC oil was applied daily (70 ¥ìL, 6 times week) on the dorsal skin for 4 weeks. Saline or jojoba oil was used for the control mice. Blood was collected after second DNCB challenge, and at 2 and 4 weeks after initiating oil application. Serum IgE levels were significantly lowered in the GC oil application group at the end of the 4-week application period. The GC oil application for 4 weeks resulted in reduction in serum IgG1 level compared with that after 2-week application. The GC oil application group showed a significantly lower serum histamine level than the control group 2 weeks after oil application. Scratching frequency of the GC oil application group was significantly lower than either control groups. This study is to demonstrate GC oil¡¯s immunoregulatory potential for alleviating atopic dermatitis through influencing of Th2 cell activation.
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KEYWORD
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atopic dermatitis, cytokine, German chamomile oil, IgE, mice
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