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KMID : 0893420110120020143
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Journal of Veterinary Science
2011 Volume.12 No. 2 p.143 ~ p.150
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Comparison of bare metal stent and paclitaxel-eluting stent using a novel rat aorta stent model
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Kwon Jin-Sook
Park Rho-Kwan
Shim Tae-Jin
Jeong Myung-Ho
Cho Myeong-Chan
Ahn Young-Keun
Kim Dong-Woon
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Abstract
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The purpose of our study was to create a novel rat aorta stent implantation model. Stainless steel bare metal stents (BMS) or paclitaxel-eluting stents (PES) were implanted in male Sprague-Dawley rats (BW 400 ± 20 g). Two and four weeks after stent implantation, the aorta were collected, fixed with 2% glutaraldehyde, and cut into two segments. One segment was used for scanning electron microscopy analysis to evaluate re-endothelialization, and the other segment was used to calculate the neointimal area. At 2 weeks after stenting, the appearance of neointimal hyperplasia was less in the PES group than in the BMS group. At 4 weeks after stenting, no significant difference in neointimal hyperplasia was observed between two groups. On the other hand, the PES group showed more thrombus formation and less re-endothelialization compared to the BMS group. This study demonstrated the ability of a novel rat model of aorta stenting via a common carotid artery to measure the efficacy and safety of commercially available drug-eluting stents.
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KEYWORD
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aorta, neointimal hyperplasia, rat, re-endothelialization, stents
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