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KMID : 0893420110120020187
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Journal of Veterinary Science
2011 Volume.12 No. 2 p.187 ~ p.190
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Maturation of bone marrow-derived dendritic cells by a novel β-glucan purified from Paenibacillus polymyxa JB115
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Ko Eun-Ju
Byon Yun-Young
Jee Young-Heun
Shin Tae-Kyun
Park Seung-Chun
Hahn Tae-Wook
Joo Hong-Gu
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Abstract
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We investigated the immunostimulatory effects of a novel β-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. β-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs. β-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with β-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of β-glucan on DC maturation and may increase the use of β-glucan.
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KEYWORD
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dendritic cells, JB115, maturation, Paenibacillus polymyxa, β-glucan
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