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KMID : 0893420120130010001
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Journal of Veterinary Science
2012 Volume.13 No. 1 p.1 ~ p.6
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Fast neutron irradiation deteriorates hippocampus-related memory ability in adult mice
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Yang Mi-Young
Kim Hwan-Seong
Kim Ju-Hwan
Kim Sung-Ho
Kim Jong-Choon
Bae Chun-Sik
Kim Joong-Sun
Shin Tae-Kyun
Moon Chang-Jong
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Abstract
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Object recognition memory and contextual fear conditioning task performance in adult C57BL/6 mice exposed to cranial fast neutron irradiation (0.8 Gy) were examined to evaluate hippocampus-related behavioral dysfunction following acute exposure to relatively low doses of fast neutrons. In addition, hippocampal neurogenesis changes in adult murine brain after cranial irradiation were analyzed using the neurogenesis immunohistochemical markers Ki-67 and doublecortin (DCX). In the object recognition memory test and contextual fear conditioning, mice trained 1 and 7 days after irradiation displayed significant memory deficits compared to the sham-irradiated controls. The number of Ki-67- and DCX-positive cells decreased significantly 24 h post-irradiation. These results indicate that acute exposure of the adult mouse brain to a relatively low dose of fast neutrons interrupts hippocampal functions, including learning and memory, possibly by inhibiting neurogenesis.
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KEYWORD
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fast neutron, hippocampus, learning and memory, neurogenesis
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