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KMID : 0893420120130020199
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Journal of Veterinary Science
2012 Volume.13 No. 2 p.199 ~ p.201
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Evaluation of modified vaccinia virus Ankara expressing VP2 protein of infectious bursal disease virus as an immunogen in chickens
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Zanetti Flavia Adriana
Zajac Maria Paula Del Medico
Taboga Oscar Alberto
Calamante Gabriela
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Abstract
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A recombinant modified vaccinia Ankara (MVA) virus expressing mature viral protein 2 (VP2) of the infectious bursal disease virus (IBDV) was constructed to develop MVA-based vaccines for poultry. We demonstrated that this recombinant virus was able to induce a specific immune response by observing the production of anti-IBDV-seroneutralizing antibodies in specific pathogen-free chickens. Besides, as the epitopes of VP2 responsible to induce IBDV-neutralizing antibodies are discontinuous, our results suggest that VP2 protein expressed from MVA-VP2 maintained the correct conformational structure. To our knowledge, this is the first report on the usefulness of MVA-based vectors for developing recombinant vaccines for poultry.
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KEYWORD
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chicken immunity, IBDV, MVA, VP2 protein
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