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KMID : 0893420120130020211
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Journal of Veterinary Science
2012 Volume.13 No. 2 p.211 ~ p.213
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SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
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Kang Jung-Taek
Kim Hyung-Jin
Oh Hyun-Ju
Hong So-Gun
Park Jung-Eun
Kim Min-Jung
Kim Min-Kyu
Jang Goo
Kim Dae-Yong
Lee Byeong-Chun
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Abstract
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Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes.
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KEYWORD
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hermaphrodite, intersexuality, wolf
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