|
KMID : 0893420120130040339
|
|
Journal of Veterinary Science
2012 Volume.13 No. 4 p.339 ~ p.344
|
|
|
Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL/KsJ-db/db mice
|
|
Do Sun-Gil
Park Jun-Hong
Nam Ha-Jin
Kim Jin-Bong
Lee Jae-Yong
Oh Yang-Seok
Suh Jun-Gyo
|
|
|
Abstract
|
|
|
|
Components of silk including silk fibroin have long been used as anti-diabetic remedies in oriental medicine. However, detailed mechanisms underlying these anti-diabetic effects remain unclear. In this study, we examined the anti-diabetic activity of silk fibroin hydrolysate (SFH) in C57BL/KsJ-db/db (db/db) mice, a well-known animal model of non-insulin dependent diabetes mellitus. When the db/db mice were administered SFH in drinking water for 6 weeks, hyperglycemia in the animals gradually disappeared and the level of glycosylated hemoglobin decreased, indicating that SFH plays important role in reducing the symptoms of diabetes. In addition, SFH-treated db/db mice exhibited improved glucose tolerance with increased plasma insulin levels. Immunohistochemical and morphological analyses showed that SFH up-regulated insulin production by increasing pancreatic β cell mass in the mice. In summary, our results suggest that SFH exerts anti-diabetic effects by increasing pancreatic β cell mass in a non-insulin dependent diabetes mellitus mouse model.
|
|
|
KEYWORD
|
|
|
β cell mass, db/db mouse, diabetes, HbA1c, silk fibroin
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
   
|