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KMID : 0893420130140040495
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Journal of Veterinary Science
2013 Volume.14 No. 4 p.495 ~ p.497
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Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy
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Chung Wook-Hun
Park Seon-Ah
Lee Jae-Hoon
Chung Dai-Jung
Yang Wo-Jong
Kang Eun-Hee
Choi Chi-Bong
Chang Hwa-Seok
Kim Dae-Hyun
Hwang Soo-Han
Han Hoon
Kim Hwi-Yool
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Abstract
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The use of human umbilical cord blood-derived mesenchymal stem cells for cell transplantation therapy holds great promise for repairing spinal cord injury. Here we report the first clinical trial transplantation of human umbilical cord (hUCB)-derived mesenchymal stem cells (MSCs) into the spinal cord of a dog suspected to have fibrocartilaginous embolic myelopathy (FCEM) and that experienced a loss of deep pain sensation. Locomotor functions improved following transplantation in a dog. Based on our findings, we suggest that transplantation of hUCB-derived MSCs will have beneficial therapeutic effects on FCEM patients lacking deep pain sensation.
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KEYWORD
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dog, fibrocartilaginous embolic myelopathy, human umbilical cord-derived mesenchymal stem cells, percutaneous transplantation, xenotransplantaion
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