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KMID : 0893420140150020309
Journal of Veterinary Science
2014 Volume.15 No. 2 p.309 ~ p.316
Accuracy of capillary blood 3-¥â-hydroxybutyrate determination for the detection and treatment of canine diabetic ketoacidosis
Bresciani Francesca

Pietra Marco
Corradini Sara
Giunti Massimo
Fracassi Federico
Abstract
In human medicine, diagnosis of diabetic ketoacidosis (DKA) is usually based on measurement of capillary 3-¥â-hydroxybutyrate (3-HB) with a hand held ketone sensor. This study was conducted to determine if measurement of capillary 3-HB could be useful for the diagnosis and monitoring of canine DKA. Fifteen dogs with diabetic ketosis and 10 with DKA were evaluated. Paired measurements of 3-HB of capillary and venous blood samples were analysed by the electrochemical sensor and reference method. Use of capillary 3-HB measurement during DKA management was then evaluated through simultaneous measurements of capillary 3-HB, urinary AcAc and venous blood gas analysis. Good agreement between capillary and venous 3-HB measurement was detected by the electrochemical sensor and reference method. Monitoring treatment of DKA revealed a significant correlation between capillary 3-HB and acidosis markers, while no significant correlation was observed between AcAc and acidosis markers. A cut-off value of capillary blood 3-HB >3.8 mmol/L for diagnosis of DKA resulted in 70% and 92% sensitivity and specificity. The electrochemical sensor accurately measures 3-HB concentration in both capillary and venous blood samples, is accurate in diagnosing canine DKA, and appears to reflect the patient's metabolic status during DKA treatment.
KEYWORD
acetoacetate, diabetes mellitus, dog, ketone bodies
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