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KMID : 0893420140150030443
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Journal of Veterinary Science
2014 Volume.15 No. 3 p.443 ~ p.447
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Dietary germanium biotite supplementation enhances the induction of antibody responses to foot-and-mouth disease virus vaccine in pigs
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Lee Jin-A
Jung Bock-Gie
Jung Myung-Hwan
Kim Tae-Hoon
Yoo Han-Sang
Lee Bong-Joo
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Abstract
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We evaluated the potential ability of germanium biotite (GB) to stimulate the production of antibodies specific for foot-and-mouth disease virus (FMDV). To this aim, we measured the total FMDV-specific antibody responses and IgM production after vaccination against FMD both experimentally and in the field. GB supplementation with FMDV vaccination stimulated the production of anti-FMDV antibodies, and effectively increased IFN-γ and TNF-α levels. These results suggest that GB may be a novel alternative feed supplement that can serve as a boosting agent and an immunostimulator for increasing the efficacy of FMDV vaccination in pigs.
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KEYWORD
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adjuvant-like effect, foot-and-mouth disease virus, germanium biotite
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