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KMID : 0893420140150030449
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Journal of Veterinary Science
2014 Volume.15 No. 3 p.449 ~ p.453
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Histopathological and immunohistochemical findings of primary and metastatic medullary thyroid carcinoma in a young dog
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Pireyro Pablo
Vieson Miranda D.
Ramos Vara Jose A.
Moon Larson Martha
Saunders Geoffrey
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Abstract
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This report describes the gross, histological, and immunohistochemical features of medullary thyroid carcinoma (MTC) with pulmonary metastases in a young dog. Sheets of pleomorphic cells supported by fibrous stroma characterized the primary mass, while metastatic nodules had a neuroendocrine pattern. Despite differing histologic features, all masses showed marked immunoreactivity against calcitonin and multiple neuroendocrine markers consistent with MTC. Although MTC is a well-recognized entity, it may be difficult to distinguish this mass from other thyroid neoplasms, necessitating immunohistochemical characterization.
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KEYWORD
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calcitonin, histopathology, immunohistochemistry, medullary thyroid carcinoma
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