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KMID : 0893420140150040575
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Journal of Veterinary Science
2014 Volume.15 No. 4 p.575 ~ p.578
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Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus
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Song Young-Jo
Park Woo-Jung
Lee Seul-Kee
Lee Joong-Bok
Park Seung-Yong
Song Chang-Seon
Lee Sang-Won
Seo Kun-Ho
Kang Young-Sun
Song Jae-Young
Choi In-Soo
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Abstract
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Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized with the VLPs than those of the negative control mice. Splenocytes from mice immunized with the VLPs also produced significantly greater quantities of interferon (IFN)-γ than interleukin (IL)-4 and IL-10. These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-γ production in immunized mice.
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KEYWORD
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interferon-γ, swine hepatitis E virus, virus-like particle
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