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KMID : 0893420140150040583
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Journal of Veterinary Science
2014 Volume.15 No. 4 p.583 ~ p.586
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Detection of Corynebacterium bovis infection in athymic nude mice from a research animal facility in Korea
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Kim Tae-Hyoun
Kim Dong-Su
Han Ju-Hee
Chang Seo-Na
Kim Kyung-Sul
Seok Seung-Hyeok
Kim Dong-Jae
Park Jong-Hwan
Park Jae-Hak
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Abstract
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Corynebacterium (C.) bovis infection in nude mice causes hyperkeratosis and weight loss and has been reported worldwide but not in Korea. In 2011, nude mice from an animal facility in Korea were found to have white flakes on their dorsal skin. Histopathological testing revealed that the mice had hyperkeratosis and Gram-positive bacteria were found in the skin. We identified isolated bacteria from the skin lesions as C. bovis using PCR and 16S rRNA sequencing. To the best of our knowledge, this is the first report of C. bovis infection in nude mice from Korea.
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KEYWORD
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athymic nude mice, Corynebacterium bovis, hyperkeratosis
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