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KMID : 0893420150160010127
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Journal of Veterinary Science
2015 Volume.16 No. 1 p.127 ~ p.130
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Application of vincristine-loaded platelet therapy in three dogs with refractory immune-mediated thrombocytopenia
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Park Hyung-Jin
Kim Ja-Won
Song Kun-Ho
Seo Kyoung-Won
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Abstract
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Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on mononuclear phagocytes,were introduced. After the VLPs were transfused, two dogs responded quickly withimproved clinical signs while the third dogwith recurrent IMT was euthanized due to its deteriorating condition. This case report describesthe efficacy of VLP therapy in refractory IMT patients.
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KEYWORD
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refractory immune-mediated thrombocytopenia, vincristine-loaded platelets
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