|
KMID : 0893420150160020157
|
|
Journal of Veterinary Science
2015 Volume.16 No. 2 p.157 ~ p.164
|
|
|
Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats
|
|
Yang Fan
Kang Jijun
Yang Fang
Zhao Zhensheng
Kong Tao
Zeng Zhenling
|
|
|
Abstract
|
|
|
|
New enrofloxacin microspheres were formulated, and their physical properties, lung-targeting ability, and tissue distribution in rats were examined. The microspheres had a regular and round shape. The mean diameter was 10.06 μm, and the diameter of 89.93% of all microspheres ranged from 7.0 μm to 30.0 μm. Tissue distribution of the microspheres was evaluated along with a conventional enrofloxacin preparation after a single intravenous injection (7.5 mg of enrofloxacin/kg bw). The results showed that the elimination half-life (t1/2β) of enrofloxacin from lung was prolonged from 7.94 h for the conventional enrofloxacin to 13.28 h for the microspheres. Area under the lung concentration versus time curve from 0 h to ∞ (AUC0-∞) was increased from 11.66 h·μg/g to 508.00 h·μg/g. The peak concentration (Cmax) in lung was increased from 5.95 μg/g to 93.36 μg/g. Three lung-targeting parameters were further assessed and showed that the microspheres had remarkable lung-targeting capabilities.
|
|
|
KEYWORD
|
|
|
enrofloxacin, lung-targeting, microsphere, preparation, tissue distribution
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
   
|